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Papillomatosis with Parenchymal Dissemination Post-Immunosuppression

Imaging findings

The patient initially presented with numerous pulmonary nodules, many exhibiting small central lucencies, alongside subtle thickening of the tracheal wall. Over subsequent studies, these nodules markedly increased in size and number, and the trachea developed severe, irregular, and circumferential wall thickening.

Key takeaways

This dramatic case illustrates the progression and parenchymal dissemination of papillomatosis (HPV-driven) following high-dose immunosuppression in a renal transplant recipient, emphasizing how a previously controlled infection can reactivate and spread.

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