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Calcifying Metastases from Colonic Adenocarcinoma

Imaging findings

A smoker with colonic adenocarcinoma developed a lobulated, irregular lung metastasis with cystic change; over serial follow-up studies spanning about two years of treatment, liver metastases and lung metastases progressively calcify, and previously non-calcified mediastinal lymph nodes containing tumor, including a prevascular node, develop increasing calcium content as the metastases slowly grow.

Key takeaways

Calcification developing within growing metastatic deposits and involved lymph nodes, rather than representing granulomatous disease, is a recognized phenomenon in several GI and GU malignancies, particularly mucinous colorectal and ovarian cancers, and can reflect either a tumor-intrinsic calcifying process or a treatment effect; awareness of this pattern prevents mistakenly attributing calcified adenopathy in a cancer patient to old granulomatous disease when it may in fact represent calcified tumor.

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