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Cervicothoracic Sign Localizing a Substernal Goiter

Imaging findings

Chest radiograph shows a well-defined interface along the left superior mediastinal margin that disappears at the level of the thoracic inlet as it no longer contacts aerated lung, with mild rightward tracheal displacement; the lateral view confirms the abnormality is not posterior but rather traverses the thoracic inlet. CT confirms a paratracheal mass extending into the left superior mediastinum, distinct from and displacing the adjacent left subclavian artery.

Key takeaways

A well-defined mediastinal interface that disappears at the thoracic inlet -- the cervicothoracic sign -- localizes a lesion to the thoracic inlet/neck rather than the posterior mediastinum, since only structures contacting aerated lung produce a sharp radiographic border; the most common cause of this sign is a substernal goiter, confirmed here on CT.

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