CTICasesInflammatory Myofibroblastic Tumor (ALK-Positive IMT)
Imaging findings
CT demonstrates a solitary pulmonary nodule with lobulated and slightly spiculated margins that is FDG-avid on PET, mimicking primary lung adenocarcinoma. Pathology demonstrated an ALK-positive inflammatory myofibroblastic tumor (IMT).
Key takeaways
Inflammatory myofibroblastic tumor (IMT) is a rare mesenchymal neoplasm of borderline malignant potential that can mimic primary lung cancer on CT and PET due to its spiculated margins and FDG avidity. ALK gene rearrangements are found in approximately 50% of cases. Tissue sampling is required for diagnosis, and ALK positivity has therapeutic implications as these tumors may respond to ALK inhibitors.
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