Collision Tumor: Pulmonary Hamartoma and Adenocarcinoma
Imaging findings
An initial chest radiograph depicted a subtle nodule. Nine months later, a follow-up CT revealed two adjacent lesions: a solid nodule consistent with a hamartoma (which showed no FDG uptake on PET) and an inferior, previously vague, lesion that had solidified, proven to be an invasive adenocarcinoma (highly FDG-avid on PET).
Key takeaways
This case illustrates a rare "collision tumor" where a benign pulmonary hamartoma coexists adjacent to an adenocarcinoma. While they appeared as separate entities here, there is a recognized association where carcinomas can arise within or adjacent to hamartomas. The subtle initial radiographic findings highlight the need for careful follow-up.
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