Mediastinal Metastasis from Breast Cancer simulating Thymic Rebound
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Imaging findings
CT reveals extensive soft tissue anterior to the aorta in the mediastinum, with adjacent destruction of the upper sternum. MRI with in-phase and out-of-phase imaging shows no signal dropout within the mediastinal soft tissue, indicating a lack of fat.
Key takeaways
Chemical shift ratio imaging (in/out of phase MRI) can be a helpful technique to differentiate mediastinal soft tissue, as lack of signal dropout suggests a non-fatty mass, such as metastasis, rather than thymic rebound or hyperplasia. Local spread of breast cancer through the internal mammary chain can present as mediastinal soft tissue and sternal involvement.
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