CTICasesGrowing Teratoma Syndrome
Imaging findings
CT of the chest in a young man with Klinefelter syndrome shows a history of a massive mediastinal germ cell tumor causing SVC syndrome. Following chemotherapy and surgical resection of the main mass, serial CT scans demonstrate progressive growth of multiple bilateral pulmonary masses, several containing coarse calcification. Histopathology of the resected lung masses confirms benign teratoma.
Key takeaways
Growing teratoma syndrome is a rare condition characterized by the progressive growth of benign mature teratoma masses during or after chemotherapy for malignant germ cell tumors, despite normalization of tumor markers. It is believed to represent chemotherapy-induced differentiation of malignant cells into mature teratoma. Surgical resection of the growing masses is required, as they do not respond to additional chemotherapy or radiation.
AI-assisted summary — may contain errors. Verify against the source video. Learn more
More from this webinar
- Hereditary Hemorrhagic Telangiectasia-Associated Pulmonary HypertensionCongenital
- Malignant MesotheliomaNeoplastic
- Pulmonary InfarctionVascular
- Intravascular Pulmonary MetastasesNeoplastic
- Rheumatoid Lung NoduleAutoimmune
- Congenital Pulmonary Airway MalformationCongenital
- Pericardial LymphangiomaNeoplastic
- Pulmonary Langerhans Cell HistiocytosisILD
See all cases from January 11, 2018 →