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Benign Metastasizing Leiomyomatosis

Imaging findings

Chest CT in a woman two months post-hysterectomy for uterine fibroids shows multiple well-defined, smooth pulmonary nodules. In addition, there is a well-circumscribed soft-tissue mass implanted within the right ventricular papillary muscle. Biopsy confirms benign metastasizing leiomyomatosis (BML).

Key takeaways

Benign metastasizing leiomyomatosis (BML) is a rare condition in which histologically benign uterine smooth muscle tumors (leiomyomas) embolize and grow at extrauterine sites, most commonly the lungs, and rarely the heart or bones. BML is typically seen in premenopausal women with a history of uterine surgery. The lesions are hormonally active, often regressing with menopause or hormone-deprivation therapy.

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