CTICasesAcute Exacerbation of Usual Interstitial Pneumonia (UIP)
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Imaging findings
Initial CT showed pulmonary fibrosis and emphysema, with features suggestive of usual interstitial pneumonia (UIP), including suspected honeycombing. A follow-up CT two months later revealed new diffuse ground glass opacity superimposed on the underlying emphysema and fibrosis.
Key takeaways
Acute exacerbation of UIP is a severe complication with high mortality (40-50%). It manifests as new, diffuse ground glass opacity superimposed on pre-existing fibrotic lung disease. Autopsy in this case confirmed diffuse alveolar damage (DAD) superimposed on UIP. Radiologists should be aware of this potentially fatal pattern in patients with known interstitial lung disease.
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