Granulomatous-Lymphocytic Interstitial Lung Disease
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Imaging findings
Chest CT of a patient with combined variable immunodeficiency (CVID) shows basilar-predominant, bronchovascular and subpleural nodular opacities, many with surrounding ground-glass halos. Splenomegaly is also visualized on the abdominal portions of the scan.
Key takeaways
Granulomatous-lymphocytic interstitial lung disease (GLILD) is a rare, non-infectious pulmonary manifestation of CVID that pathologically shares features with both sarcoidosis and lymphoid interstitial pneumonia (LIP). Early recognition is crucial as it typically responds to systemic immunosuppression or immunomodulatory therapy rather than antibiotics.
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