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Granulomatous-Lymphocytic Interstitial Lung Disease

Granulomatous-Lymphocytic Interstitial Lung Disease▶ Watch on YouTube — age-restricted, cannot embed here

Imaging findings

Chest CT of a patient with combined variable immunodeficiency (CVID) shows basilar-predominant, bronchovascular and subpleural nodular opacities, many with surrounding ground-glass halos. Splenomegaly is also visualized on the abdominal portions of the scan.

Key takeaways

Granulomatous-lymphocytic interstitial lung disease (GLILD) is a rare, non-infectious pulmonary manifestation of CVID that pathologically shares features with both sarcoidosis and lymphoid interstitial pneumonia (LIP). Early recognition is crucial as it typically responds to systemic immunosuppression or immunomodulatory therapy rather than antibiotics.

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