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Exogenous Lipoid Pneumonia

Imaging findings

CT shows a solitary, low-attenuation (negative 20 to negative 30 HU, indicating fat density) pulmonary nodule in the lower lobe with adjacent bronchiectasis and fluid layering. The nodule is FDG-negative on PET. The patient was on Miralax and nasal fluticasone (Flonase) spray.

Key takeaways

Exogenous lipoid pneumonia is caused by the aspiration of lipid-containing substances, which can present as a localized low-attenuation/fatty mass or consolidation mimicking a neoplasm (e.g. hamartoma or metastasis). Chronic use of nasal steroid sprays (like fluticasone) or mineral oils is a recognized cause of silent lipid aspiration.

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