CTICasesAdenocarcinoma, Lepidic Predominant, with Ground Glass Opacity
Imaging findings
Lung cancer screening CT shows a left lower lobe lesion that, on prior imaging (two years earlier), was a subtle ground glass opacity. It progressed to a larger ground glass opacity with some residual distorted airspaces (possibly a patent bronchus), but no solid component. Pathology confirmed adenocarcinoma, lepidic predominant.
Key takeaways
Ground glass opacities, especially those with interval growth or featuring distorted airspaces (like patent bronchi) without a solid component, are characteristic of lepidic-predominant adenocarcinoma (formerly adenocarcinoma in situ or minimally invasive adenocarcinoma with lepidic growth). Long-term follow-up in screening programs can demonstrate the subtle evolution of these lesions.
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