CTICasesDisseminated MAC Infection with Interferon-Gamma Autoantibodies
Imaging findings
Chest CT shows mediastinal lymphadenopathy and an upper lobe nodule with surrounding perilymphatic nodules. PET CT demonstrates intense, diffuse uptake throughout the lungs, lymph nodes, and bone marrow without destructive bone lesions, and bone marrow biopsy confirmed MAC growth.
Key takeaways
Disseminated Mycobacterium avium complex (MAC) infection presenting with diffuse lymphadenopathy and bone marrow disease can be associated with autoantibodies to interferon-gamma, which mimics genetic immunodeficiencies and impairs intracellular pathogen clearance.
AI-assisted summary — may contain errors. Verify against the source video. Learn more
More from this webinar
- Pacemaker Lead DislodgementIatrogenic
- Williams-Campbell SyndromeCongenital
- Chronic Beryllium DiseaseExposure
- Chondromyxoid Fibroma of the RibNeoplastic
See all cases from April 28, 2022 →