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Chondromyxoid Fibroma of the Rib

Imaging findings

Chest radiograph and CT show an expansile, well-circumscribed right rib lesion containing a matrix mix of fat, calcium, and soft tissue, with cortical thinning but no aggressive periosteal reaction. Resection specimen confirms a lobulated cartilaginous mass.

Key takeaways

Chondromyxoid fibroma is a rare, benign primary cartilaginous bone tumor. When arising from the rib or chest wall, it can mimic malignant primary tumors like chondrosarcoma, requiring histopathological confirmation for diagnosis.

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