CTICasesZygomycosis in GATA2 deficiency
Imaging findings
Chest CT in a patient with GATA2 deficiency (MonoMAC syndrome) and AML shows rapidly progressive, large consolidative masses with a central lacy lucency and dense peripheral rim (bird's nest sign), accompanied by a large pleural effusion and pericardial fluid. Cultures confirmed zygomycosis.
Key takeaways
Zygomycosis is an aggressive, angioinvasive fungal infection in immunocompromised hosts, such as those with GATA2 deficiency. The bird's nest sign on CT represents a pattern of central necrosis and tissue destruction, reflecting the angioinvasive nature of the infection.
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