CTICasesRheumatoid Arthritis-Associated Interstitial Lung Disease (UIP with Exuberant Honeycombing)
Imaging findings
High-resolution CT demonstrates highly asymmetric, upper- and mid-lung predominant subpleural fibrosis and traction bronchiectasis. Over time, this progresses directly to a pattern of "exuberant" honeycombing with minimal preceding reticulation.
Key takeaways
Exuberant honeycombing is a distinct fibrotic phenotype highly associated with connective tissue disease, particularly rheumatoid arthritis. Unlike classic idiopathic pulmonary fibrosis, this pattern features extensive, clustered cystic spaces that often do not show a basal predominance and can develop rapidly without a prolonged intermediate phase of reticular opacities.
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