CTICasesAntisynthetase Syndrome (Anti-EJ/glycyl-tRNA synthetase)
Imaging findings
Initial chest CT shows extensive, bilateral, and multi-lobar ground-glass opacities and consolidations, primarily concentrated in the lower lung zones. Follow-up CT performed several months later shows a significant decrease in active consolidative opacities, but with residual reticulation, traction bronchiectasis, and architectural distortion at the lung bases, representing evolving fibrotic interstitial lung disease.
Key takeaways
Antisynthetase syndrome is an autoimmune, myositis-associated interstitial lung disease (ILD) that can be linked to multiple anti-aminoacyl-tRNA synthetase antibodies, including anti-Jo-1, anti-PL-7, anti-PL-12, and anti-EJ. Patients frequently present with acute or subacute respiratory symptoms mimicking community-acquired pneumonia, with underlying histopathology typically showing a combination of organizing pneumonia (OP) and non-specific interstitial pneumonia (NSIP).
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