CTICasesRecurrent Lymphangioleiomyomatosis (LAM) Post-Lung Transplant
Imaging findings
Historical chest radiographs and film CT show bilateral pleural effusions and reticular abnormalities. Post-transplant CT demonstrates a recurrent pattern of scattered, small, thin-walled lung cysts in the donor lungs, which are highlighted particularly well on expiratory CT scans.
Key takeaways
Lymphangioleiomyomatosis (LAM) is one of the rare pulmonary diseases that can recur in the donor lung after transplantation. The recurrence is driven by circulating, low-grade metastatic LAM cells of host origin that colonize the donor lungs. Recurrent cysts typically manifest several years post-transplant and can be pathologically confirmed via biopsy.
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