CTICasesAntisynthetase Syndrome (Anti-Jo-1)
Imaging findings
Chest CT shows confluent, consolidative lower-lung opacities involving multiple segments. Follow-up imaging shows persistent basal ground-glass opacities, traction bronchiectasis, and focal areas of architectural distortion alongside new patchier consolidations. Concomitant thigh MRI shows muscle signal hyperintensity on fluid-sensitive sequences, confirming active inflammatory myositis.
Key takeaways
Anti-Jo-1 is the most common autoantibody associated with antisynthetase syndrome. The clinical presentation classically includes a triad of interstitial lung disease, myositis, and cutaneous abnormalities such as mechanic's hands or Gottron's papules. Incorporating skeletal muscle MRI is a valuable adjunct to confirm active muscle inflammation in patients presenting with unexplained progressive dyspnea and limb weakness.
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