CTICasesNaganishia (Cryptococcus) Pulmonary Infection
Imaging findings
Chest CT in an immunocompromised patient demonstrates a dense, consolidative lingular mass with a necrotic center, exhibiting a thick-walled 'bird's nest' appearance. The mass is in direct contact with the mediastinum and pericardium, associated with a new pericardial effusion and surrounding ground-glass opacity suggestive of alveolar hemorrhage.
Key takeaways
Naganishia (formerly classified as atypical Cryptococcus species, such as Naganishia albida) is an emerging, opportunistic fungal pathogen capable of causing severe necrotizing pneumonia in severely immunocompromised individuals, such as patients with acute myeloid leukemia (AML). Radiographically, its highly aggressive, invasive nature and propensity for central necrosis can closely mimic angioinvasive aspergillosis or mucormycosis.
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