CTICasesAlveolar Proteinosis with Complete Response to GM-CSF Therapy
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Imaging findings
A chest radiograph showed diffuse lung disease with some areas of spared lung. CT demonstrated a beautiful 'crazy paving' pattern, characterized by ground glass opacities with superimposed interlobular septal thickening. Post-treatment images showed complete resolution of the imaging findings.
Key takeaways
Alveolar proteinosis is classically characterized by the 'crazy paving' pattern on CT. While whole lung lavage is a standard treatment, some patients do not respond to lavage and require granulocyte-macrophage colony-stimulating factor (GM-CSF) replacement therapy. A complete response to GM-CSF therapy is unusual but can occur.
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