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Granulomatosis with polyangiitis

Imaging findings

Chest radiograph and CT show rapidly progressive, uniform bilateral consolidations and ground-glass opacities, with subsequently developed pneumothorax and pneumomediastinum. Autopsy confirmed extensive pulmonary hemorrhage, acute respiratory distress syndrome, and systemic vasculitis involving the kidneys.

Key takeaways

Granulomatosis with polyangiitis can rarely present with fulminant diffuse alveolar hemorrhage and rapid progression to severe ARDS and death within days. Renal involvement is a common systemic association, whereas sinus involvement may be absent.

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