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Chronic Lipoid Pneumonia

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Imaging findings

Areas of focal centrilobular consolidation with calcification and architectural distortion are present, noted to be stable over several years. Crucially, on soft tissue windows, these consolidations exhibit fat attenuation, which is pathognomonic. The architectural distortion is a result of a granulomatous and fibrotic response.

Key takeaways

Chronic lipoid pneumonia results from the aspiration or inhalation of exogenous fatty substances, leading to a granulomatous and fibrotic inflammatory response in the lung. The hallmark imaging finding is the presence of fat attenuation within areas of consolidation. This condition can cause architectural distortion and mimic malignancy, emphasizing the importance of fat quantification on CT.

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