CTICasesBleomycin-Induced Severe Alveolar Damage with Barotrauma
▶ Watch on YouTube — age-restricted, cannot embed here
Imaging findings
Initial chest radiograph and CT show diffuse lung disease with crazy paving, some more dependent consolidation, and interesting peripheral sparing, consistent with acute lung injury. Follow-up imaging shows pneumothorax, subcutaneous gas, and pneumomediastinum (barotrauma). Later images reveal a finer ground glass pattern and somewhat dilated airways, with diffuse pneumomediastinum. Over time, the lungs slowly cleared.
Key takeaways
This case demonstrates the progression of severe alveolar damage induced by Bleomycin chemotherapy, complicated by barotrauma. The initial non-specific pattern of acute lung injury evolves with diffuse ground glass and pneumomediastinum. Despite severe acute changes and barotrauma, the lungs in this case cleared without expected residual fibrosis, highlighting the potential for recovery from drug-induced lung injury.
AI-assisted summary — may contain errors. Verify against the source video. Learn more
More from this webinar
- Pneumocystis Pneumonia (PCP) and Companion CMV PneumoniaInfection
- Pseudoaneurysm at Cannulation Site Post-CABGVascular
- Fungating Soft Tissue Chloroma with Lung Nodules/InfiltrationNeoplastic
- Posterior Sternoclavicular Joint Dislocation (Left)Trauma
- Chondrosarcoma of RibNeoplastic
- Constrictive Bronchiolitis in Rheumatoid ArthritisAutoimmune
- Esophageal Perforation (Post-Stent)Iatrogenic
- Tracheoesophageal Fistula (Post-Radiation for Tracheal SCC)Iatrogenic
See all cases from August 28, 2015 →
Related ILD cases
- Hypersensitivity Pneumonitis (HP) in a Dog Groomer
- Methotrexate-induced Lung Toxicity (Organizing Pneumonia)
- Systemic Sclerosis-associated Nonspecific Interstitial Pneumonia (NSIP) - Progression
- Desquamative Interstitial Pneumonia (DIP)
- Amiodarone-induced Organizing Pneumonia
- Fibrotic Hypersensitivity Pneumonitis