CTICasesKappa Light Chain Deposition Disease
Imaging findings
Chest CT demonstrates a few non-specific upper lung findings, multiple ill-defined nodules in the lung bases, scattered small cystic abnormalities along the airways, and a localized calcification or ossification in the right lung base.
Key takeaways
Non-amyloid light chain deposition disease is a rare systemic disorder characterized by the tissue deposition of monoclonal immunoglobulin light chains, frequently associated with a plasma cell dyscrasia or lymphoproliferative disorder. Pulmonary manifestations can include parenchymal nodules, thin-walled cysts, and calcifications or bone formation triggered by protein deposition.
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