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Pulmonary Adenocarcinoma with Pseudo-Cavitation

Imaging findings

Thin-section CT scans in two different patients demonstrate irregular, bubble-like air spaces (pseudo-cavitation) within ground-glass and solid pulmonary nodules. The lesions exhibit distorted internal air spaces with minimal solid tissue, mostly displaying lepidic growth characteristics along the periphery.

Key takeaways

Pseudo-cavitation or irregular cystic spaces within a pulmonary nodule are highly correlated with adenocarcinoma, often reflecting lepidic growth patterns with spared or bronchiectatic air spaces rather than true ischemic necrosis. These slow-growing lesions can easily be overlooked on screening or mistaken for benign cystic airspaces, making familiarity with this pattern essential.

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