CTICasesAggressive Adenocarcinoma in CPFE
Imaging findings
Serial CT chest scans in a patient with combined pulmonary fibrosis and emphysema (CPFE) show a small apical nodule that rapidly progressed over several months to demonstrate extensive lymphangitic spread and pleural nodular seeding.
Key takeaways
Patients with combined pulmonary fibrosis and emphysema (CPFE) have a significantly increased risk of developing primary lung cancer. These tumors can behave highly aggressively, presenting with rapid local progression, lymphangitic spread, and pleural metastasis.
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