CTICasesRespiratory Papillomatosis with Malignant Transformation to Squamous Cell Carcinoma
Imaging findings
Chest CT demonstrates a large, solid central mass with low-attenuation necrotic components in the right lower and middle lobes, crossing the major fissure, as well as several smaller bilateral solid pulmonary nodules. The central trachea is mostly spared of mucosal nodularity, but the patient had a known history of recurrent laryngeal papillomas.
Key takeaways
Respiratory papillomatosis, typically caused by the human papillomavirus (HPV), carries a risk of malignant transformation into squamous cell carcinoma. This transformation typically presents as rapidly growing, solid, or cavitating parenchymal masses and nodules, necessitating aggressive surgical management such as lobectomy or bilobectomy.
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