CTICasesNUT Midline Carcinoma of the Mediastinum
Imaging findings
CT chest shows a large, aggressive, infiltrative anterior mediastinal mass directly invading the trachea, causing severe airway narrowing, stridor, and tracheal displacement, associated with mediastinal lymphadenopathy.
Key takeaways
NUT midline carcinoma is an extremely aggressive, poorly differentiated epithelial neoplasm characterized by a chromosomal rearrangement of the NUT gene. It has a high propensity for midline structures of the thorax, presenting as a rapidly growing mediastinal mass that causes critical airway obstruction and carries a very poor prognosis.
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