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Hypertrophic Osteoarthropathy in Lung Cancer

Imaging findings

Radiographs of the lower extremities show symmetric, smooth, periosteal reaction and new bone formation along the diaphyses of the tibiae and fibulae. Chest CT shows a primary lung mass, confirmed as adenocarcinoma.

Key takeaways

Hypertrophic osteoarthropathy (HPO) is a classic paraneoplastic syndrome most commonly associated with non-small cell lung cancer (especially adenocarcinoma). It presents with clubbing and painful, symmetric periosteitis of the long bones, which can be the initial clinical presentation leading to the diagnosis of lung cancer.

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