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Splenosis

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Imaging findings

An incidental soft tissue nodule is noted in the left pleural space, along with multiple similar enhancing nodules in the left pleural space, abdomen, and pelvis. The spleen is absent. Evidence of prior trauma, including multiple rib fractures, is present. A PET scan showed diffuse background uptake in these nodules, similar to normal splenic tissue.

Key takeaways

Splenosis is the autotransplantation of splenic tissue, typically following traumatic splenic rupture and splenectomy. These ectopic splenic implants can present as soft tissue nodules in the pleural space or abdomen, mimicking malignancy, but they enhance similarly to the spleen and may demonstrate PET avidity.

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