CTICasesSjogren's Syndrome with NSIP, Follicular Bronchiolitis, and Cysts (mimicking honeycombing)
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Imaging findings
Numerous peripheral cysts are present, closely mimicking honeycombing, along with some bronchiectasis and bronchiolectasis. Airways can be followed through many of these cystic areas. Pathology revealed advanced interstitial fibrosis, specifically an NSIP pattern, with prominent follicular bronchiolitis and germinal centers. The cysts are theorized to be related to these lymphoid aggregates.
Key takeaways
Connective tissue diseases like Sjogren's syndrome can manifest with cystic lung disease, often associated with follicular bronchiolitis and lymphoid aggregates. These cysts can extensively mimic honeycombing, but their underlying pathology and origin (related to lymphoid tissue rather than typical fibrotic remodeling) can be distinct.
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