CTICasesCapillary Leak Syndrome in Chronic GVHD
Imaging findings
CT chest and radiographs show large, persistent, bilateral pleural effusions, pericardial effusion, and generalized, severe subcutaneous soft tissue edema throughout the chest wall, in a patient with chronic graft-versus-host disease (GVHD).
Key takeaways
Vascular endothelial/capillary leak syndrome is a rare and severe manifestation of chronic GVHD following allogeneic stem cell transplantation. It is characterized by persistent serositis (pleural/pericardial effusions) and generalized anasarca. The pathogenesis involves cytokine-mediated endothelial damage and increased vascular permeability.
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