CTICasesCapillary Leak Syndrome in Chronic GVHD
[...]. Capillary Leak Syndrome in Chronic GVHD. CTICases. Published April 16, 2020. https://cticases.com/c/mhhac
Imaging findings
CT chest and radiographs show large, persistent, bilateral pleural effusions, pericardial effusion, and generalized, severe subcutaneous soft tissue edema throughout the chest wall, in a patient with chronic graft-versus-host disease (GVHD).
Key takeaways
Vascular endothelial/capillary leak syndrome is a rare and severe manifestation of chronic GVHD following allogeneic stem cell transplantation. It is characterized by persistent serositis (pleural/pericardial effusions) and generalized anasarca. The pathogenesis involves cytokine-mediated endothelial damage and increased vascular permeability.
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