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Subpleural Fat Hypertrophy in Chronic Pleural Disease

Imaging findings

CT demonstrates a persistent pleural effusion and pleural thickening with a chest tube in place. There is marked thickening and prominence of the extrapleural/subpleural fat layer adjacent to the thickened parietal pleura, along with inflammatory edema and increased attenuation within the overlying chest wall fascia.

Key takeaways

Hypertrophy of the extrapleural fat is a common, benign response to chronic pleural inflammation, such as that seen in empyema, tuberculosis, or chronic effusions. Identifying this thickened fat layer on CT helps confirm the chronicity of the pleural process and assists in identifying the true boundary of the chest wall.

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