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Fibrosing mediastinitis without calcification

Imaging findings

CTA of a young female shows right lung volume loss and a non-calcified right hilar soft-tissue mass compressing the right lower lobe pulmonary artery, right upper lobe bronchus, and right superior pulmonary vein, causing severe perfusion defects.

Key takeaways

Fibrosing mediastinitis is typically caused by Histoplasma capsulatum and classically presents with calcified mediastinal/hilar masses. Rare non-calcified cases can occur, mimicking lung cancer or sarcoma, and are characterized by vascular and airway stenosis.

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