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Granulomatous-lymphocytic interstitial lung disease (GLILD) in CVID

Imaging findings

CT scan of a patient with common variable immunodeficiency (CVID) shows diffuse bronchocentric nodules, splenomegaly, and consolidation with mild traction bronchiectasis, which resolved completely following treatment with sirolimus and prednisone.

Key takeaways

Granulomatous-lymphocytic interstitial lung disease (GLILD) is a clinicopathologic complication of CVID. It is characterized by lymphocytic infiltration and granulomatous inflammation, mimicking sarcoidosis, and is highly responsive to immunosuppressive therapy.

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