CTICasesAcute exacerbation of idiopathic pulmonary fibrosis
Imaging findings
Chest CT shows a baseline UIP pattern with subpleural reticulation, honeycombing, and traction bronchiectasis. Following radiation therapy for metastatic neuroendocrine carcinoma, CT shows new, diffuse ground-glass opacities superimposed on the fibrotic lung.
Key takeaways
Chest radiation therapy can trigger an acute exacerbation of underlying idiopathic pulmonary fibrosis. This presents as rapidly progressive, diffuse ground-glass opacities and carries a very high mortality rate.
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