CTICasesMetastatic Squamous Cell Carcinoma Mimicking Angiosarcoma
Imaging findings
Contrast-enhanced chest CT demonstrates a large, lobulated, enhancing soft-tissue mass centered in the right atrioventricular groove, associated with an aggressive, nodular pericardial effusion. Biopsy of the mass revealed metastatic squamous cell carcinoma, matching the patient's previous primary cutaneous squamous cell carcinoma of the leg.
Key takeaways
Primary cardiac angiosarcoma typically arises in the right atrium or atrioventricular groove, presenting as an aggressive, enhancing mass with pericardial involvement. However, metastatic disease (such as melanoma, renal cell carcinoma, or squamous cell carcinoma) can occasionally hematogenously spread to the myocardium and perfectly mimic this appearance.
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