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Parathyroid Adenoma

Imaging findings

Chest CT shows a large, well-circumscribed, soft-tissue mass located posterior to the right lobe of the thyroid gland in the superior mediastinum. A technetium-99m sestamibi scan demonstrated intense, persistent radiotracer uptake, confirming a giant parathyroid adenoma in a patient with severe hypercalcemia and hyperparathyroidism.

Key takeaways

Parathyroid adenomas are usually small (the size of a lymph node) but can occasionally grow into giant masses, mimicking thyroid goiter or other mediastinal neoplasms. Sestamibi scintigraphy is highly sensitive and specific for localizing these hyperfunctioning lesions, which can be found in ectopic locations such as the mediastinum.

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