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Progressive and Destructive Mycobacterium Avium Complex (MAC) in an Adult Male (Case 1)

Progressive and Destructive Mycobacterium Avium Complex (MAC) in an Adult Male (Case 1)▶ Watch on YouTube — age-restricted, cannot embed here

Imaging findings

Initial scans show nodules and consolidation in the upper lobe, peripheral scarring, and tree-in-bud opacities, with striking asymmetry. Subsequent progression involved a significant flare with consolidation and cavitation in the right lower lung, extensive scarring, bronchiectasis, and progressive volume loss, ultimately developing areas resembling honeycombing and further cavitation.

Key takeaways

This case illustrates aggressive and rapidly progressive Mycobacterium Avium Complex (MAC) infection in a middle-aged male, presenting with severe cavitary and destructive lung disease that significantly worsened over several months. The dramatic asymmetry, extensive scarring, bronchiectasis, and cavitation are prominent features, diverging from typical MAC patterns often seen in older women with nodular bronchiectatic disease. The possibility of superimposed aspiration is also considered given the distribution.

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