CTICasesBruton's Agammaglobulinemia with Chronic Bronchial Disease
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Imaging findings
Serial chest radiographs showed progressive changes over time. CT revealed diffuse bronchial wall thickening, particularly conspicuous in the right upper lobe. There was also evidence of cicatrization atelectasis in the left lower lobe, with patent but crowded bronchi, and patchy opacities presumably from scarring due to repeated infections. Some potential cystic spaces or air trapping were also noted.
Key takeaways
Bruton's agammaglobulinemia, a primary immunodeficiency, predisposes individuals to recurrent bacterial infections, especially in the bronchi. This leads to chronic bronchial wall thickening, bronchiectasis (often basal-predominant), and, in severe cases, cicatrization atelectasis and scarring, reflecting the long-term sequelae of impaired immune function.
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