CTICasesSarcomatoid mesothelioma
Imaging findings
Chest CT shows a very thick, nodular pleural rind in the left pleural space with large, chunky matrix calcification conforming to osteoid or chondroid differentiation, extending into the mediastinum, extrapleural fat, and interlobar fissures, causing mass effect and compression on the adjacent airway in a patient with asbestos exposure.
Key takeaways
Sarcomatoid mesothelioma is a highly aggressive histological subtype of malignant mesothelioma. Unlike the more common epithelioid subtype, it can show heterologous differentiation (such as osteosarcomatous or chondrosarcomatous differentiation) manifesting as dense, chunky matrix calcification within a pleural rind.
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