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Post-Transplant Lymphoproliferative Disorder

Post-Transplant Lymphoproliferative Disorder▶ Watch on YouTube — age-restricted, cannot embed here

Imaging findings

Chest CT in a lung transplant recipient shows multiple large, well-circumscribed lung nodules and masses in the non-transplanted native left lung, some containing patent but distorted airways, along with marked enlargement of the left adrenal gland. Adrenal biopsy confirmed a high-grade large B-cell non-Hodgkin lymphoma.

Key takeaways

Post-transplant lymphoproliferative disorder is a life-threatening complication of immunosuppression following solid organ transplantation, frequently associated with Epstein-Barr virus. It can manifest atypically with lung masses and extranodal abdominal involvement, such as adrenal enlargement, mimicking metastatic carcinoma.

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