CTICasesEosinophilic Granulomatosis with Polyangiitis (EGPA)
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Imaging findings
Chest radiographs and subsequent CT demonstrate bilateral, multifocal perihilar consolidation, ground-glass opacities, and associated interlobular septal thickening, raising initial suspicion for pulmonary hemorrhage.
Key takeaways
Also known as Churg-Strauss syndrome, this systemic necrotizing vasculitis classically presents in asthmatic patients with eosinophilic sinusitis, peripheral eosinophilia, neuropathy, and multiorgan involvement. Skin biopsy can demonstrate eosinophilic vasculitis with perineural and neural eosinophilic infiltration. Although classically associated with ANCA positivity, a significant proportion of patients can be ANCA-negative.
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