CTICasesRET-Rearranged Lung Adenocarcinoma
Imaging findings
Chest CT of a 57-year-old male never-smoker shows a large, necrotic mass in the left upper lobe and diffuse, widespread bilateral 'Cheerio' (cavitary/halo) nodules, along with extensive osteoblastic/sclerotic bone metastases.
Key takeaways
RET fusion-positive lung adenocarcinoma typically occurs in young never-smokers and is characterized by a high propensity for early, widespread hematogenous dissemination (miliary/cavitary metastases) and bone metastases.
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