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Early Pulmonary Veno-Occlusive Disease

Imaging findings

Chest CT of an asymptomatic marathon runner shows prominent interlobular septal thickening and complex veno-venous collaterals. Direct pulmonary catheter angiography confirms venous-to-venous collateral pathways without AV shunting. Diffusion capacity and hemodynamics are normal.

Key takeaways

Pulmonary veno-occlusive disease (PVOD) can present in an early, physiologically asymptomatic phase with prominent septal lines and veno-venous collaterals. Biopsy should be avoided when PVOD is suspected, though this early form can be clinically silent.

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