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Pulmonary Metastases with "Cheerio" Sign (GI Adenocarcinoma)

Pulmonary Metastases with "Cheerio" Sign (GI Adenocarcinoma)▶ Watch on YouTube — age-restricted, cannot embed here

Imaging findings

Chest radiograph and CT in a patient with esophageal cancer show multiple scattered pulmonary nodules. Several of these nodules demonstrate central lucency or cavitation, resembling "cheerios" (the cheerio sign). The nodules are predominant in the lower lung zones.

Key takeaways

The "cheerio" sign refers to a pulmonary nodule with a central air-filled cavity or patent airway. While classic for Langerhans cell histiocytosis (LCH) and adenocarcinoma of the lung, it can also be seen in hematogenous metastases, particularly from mucinous or gastrointestinal adenocarcinomas (such as esophageal, gastric, or colorectal cancers).

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