CTICasesWaxing and Waning Granulomatous-Lymphocytic Interstitial Lung Disease (GLILD)
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Imaging findings
A patient with GLILD (associated with CVID, though biopsy report was unavailable). Imaging showed an admixture of nodules, patchy ground-glass opacities, and non-segmental ground-glass opacities. Serial imaging over several months demonstrated a dynamic pattern where some lesions disappeared while new lesions appeared in other areas, exhibiting spontaneous waxing and waning of parenchymal opacities.
Key takeaways
This case provides a great example of the waxing and waning phenomenon observed in GLILD, where pulmonary opacities can spontaneously appear and resolve over time, even in the absence of specific therapy and often in asymptomatic patients. This characteristic behavior poses a dilemma regarding the frequency of follow-up imaging and the need for intervention based solely on new imaging findings.
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