CTICasesDaptomycin-Induced Pulmonary Toxicity
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Imaging findings
Chest CT shows diffuse lung disease characterized by perilobular consolidation, ground-glass opacities, and prominent septal lines, with classic subpleural sparing and an absence of pleural effusions. Laboratory evaluation documented the development of peripheral eosinophilia, which peaked at 10% following the CT scan.
Key takeaways
Daptomycin-induced pulmonary toxicity is a known drug reaction that can manifest as acute eosinophilic pneumonia, organizing pneumonia, or acute fibrinous and organizing pneumonia (AFOP). The condition is highly responsive to drug discontinuation and systemic corticosteroid therapy, typically resulting in rapid clinical improvement and normalization of peripheral eosinophil counts.
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