CTICasesRapid Progression of Metastatic Cervical Cancer with Lymphangitic Carcinomatosis
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Imaging findings
Initial imaging revealed a very large pelvic mass and metastatic disease to regional pelvic and cervical lymph nodes. Follow-up chest imaging just three weeks later showed dramatic progression, including bilateral pleural effusions, extensive interstitial lung edema (septal lines, peribronchial fluid cuffs), marked mediastinal lymph node enlargement, and a diffuse infiltrative process in the mediastinum, indicative of lymphangitic carcinomatosis. Autopsy confirmed widespread metastatic tumor involvement, including the lungs.
Key takeaways
Cervical cancer can exhibit aggressive and rapid metastatic progression, including lymphangitic carcinomatosis and extensive mediastinal involvement, leading to severe pulmonary edema and pleural effusions. Such rapid deterioration can be alarming to clinicians, who might initially consider infection. This case highlights the importance of recognizing the pattern of extensive lymphatic and interstitial tumor spread in the context of known malignancy, even with rapid onset of symptoms.
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